DUBAI, United Arab Emirates (AP) — Iran launched missiles at Israel early today as aerial attacks in the Middle East commenced for a sixth day after an American submarine sank an Iranian warship and Iran threatened the destruction of military and economic infrastructure across the region.

Israel announced multiple incoming attacks, and air sirens sounded in Tel Aviv and Jerusalem shortly after the Israeli military said it had begun new strikes in Lebanon targeting the Iranian-backed Hezbollah militant group in Beirut’s southern suburbs.

The fighting continued after the U.S. and Israel intensified their bombardment of Iran on Wednesday.

The tempo of the strikes on Iran was so intense that state television announced the mourning ceremony for Iranian Supreme Leader Ayatollah Ali Khamenei, who was killed at the start of the conflict, would be postponed. Millions attended the funeral of his predecessor, Ayatollah Ruhollah Khomeini, in 1989.

The U.S. and Israel launched the war Saturday, targeting Iran’s leadership, missile arsenal and nuclear program while suggesting that toppling the government is a goal. But the exact aims and timelines have repeatedly shifted, signaling an open-ended conflict.

President Donald Trump praised the U.S. military Wednesday for “doing very well on the war front, to put it mildly.” Fellow Republicans in the U.S. Senate stood with Trump on Iran as they voted down a resolution seeking to halt the war.

Iran fired on Bahrain, Kuwait and Israel as the conflict spiraled. Turkey said NATO defenses intercepted a ballistic missile launched from Iran before it entered Turkey’s airspace.

The war has killed more than 1,000 people in Iran, more than 70 in Lebanon and around a dozen in Israel, according to officials in those countries. It has disrupted the supply of the world’s oil and gas, snarled international shipping and stranded hundreds of thousands of travelers in the Middle East.

Neighboring countries braced for potential dangers today, a day after Iran’s paramilitary Revolutionary Guard threatened “the complete destruction of the region’s military and economic infrastructure.”

Qatar’s Interior Ministry said authorities were evacuating residents near the U.S. Embassy in Doha as a temporary precaution, without providing further details.